Neoadjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor-Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy
Abstract
Purpose: Some forms of chemotherapy can enhance antitumor immunity through immunogenic cell death, resulting in increased T-cell activation and tumor infiltration. Such effects could potentially sensitize tumors to immunotherapies, including checkpoint blockade. We investigated whether platinum- and taxane-based chemotherapy for ovarian cancer induces immunologic changes consistent with this possibility.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 14, 2017
- Source ID
- 10.1158/1078-0432.ccr-16-1433
Entities
People
- Aline Talhouk
- Blaise A. Clarke
- Brad H Nelson
- Charlotte S. Lo
- David R. Kroeger
- Derek S. Chiu
- Katy Milne
- Kurosh Rahimi
- Patricia A. Shaw
- Sanaz Sanii
Organizations
- BC Cancer Agency
- BC Cancer Foundation
- Canadian Institutes of Health Research
- United States Department of Defense
- University of British Columbia
- University of Toronto
- University of Victoria
- Université de Montréal