Immunization against HIF-1α Inhibits the Growth of Basal Mammary Tumors and Targets Mammary Stem Cells In Vivo
Abstract
Purpose: Triple-negative breast cancer (TNBC) represents a cancer stem cell–enriched phenotype. Hypoxia-inducible factor-1α (HIF-1α) induces the expression of proteins associated with stemness and is highly upregulated in TNBC. We questioned whether HIF-1α was immunogenic and whether vaccination targeting HIF-1α would impact the growth of basal-like mammary tumors in transgenic mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2017
- Source ID
- 10.1158/1078-0432.ccr-16-1678
Entities
People
- Benjamin C. Curtis
- Daniel Herendeen
- Denise L. Cecil
- Ekram Gad
- Lauren Rastetter
- Mary L. Disis
- Megan M. O'meara
- Meredith Slota
- Yushe Dang
Organizations
- National Institutes of Health
- United States Department of Defense