Personalized Medicine–Based Approach to Model Patterns of Chemoresistance and Tumor Recurrence Using Ovarian Cancer Stem Cell Spheroids
Abstract
Purpose: Chemoresistant ovarian cancers grow in suspension within the ascites fluid. To screen the effect of chemotherapeutics and biologics on resistant ovarian cancers with a personalized basis, we developed a 3D hanging drop spheroid platform.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 14, 2017
- Source ID
- 10.1158/1078-0432.ccr-17-0133
Entities
People
- Elyse M. A. Fleck
- Geeta Mehta
- Karen McLean
- Lijun Tan
- Maria R. Ward
- Michael E. Bregenzer
- Pooja Mehta
- Ronald J. Buckanovich
- Shreya Raghavan
Organizations
- National Cancer Institute
- United States Department of Defense
- University of Michigan