Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of TP53 Missense Mutation in Prostate Cancer

Abstract

Purpose: TP53 missense mutations may help to identify prostate cancer with lethal potential. Here, we preanalytically, analytically, and clinically validated a robust IHC assay to detect subclonal and focal TP53 missense mutations in prostate cancer.

Document Details

Document Type
Pub Defense Publication
Publication Date
Aug 14, 2017
Source ID
10.1158/1078-0432.ccr-17-0257

Entities

People

  • Angelo M De Marzo
  • Ashley E. Ross
  • Edward M. Schaeffer
  • Fawaz Almutairi
  • Gaurav Rajoria
  • George J. Netto
  • Kasra Yousefi
  • Liana B. Guedes
  • Michael C. Haffner
  • Rajni Sharma
  • Roberto Zoino
  • Szczepan Klimek
  • Tamara L Lotan
  • William B Isaacs
  • Zach Liu

Organizations

  • Congressionally Directed Medical Research Programs
  • Johns Hopkins University
  • National Institutes of Health

Tags

Fields of Study

  • Medicine
  • Physics

Readers

  • Aerospace Engineering
  • Molecular Biology and Genetics
  • Oncology and Biomarker-Based Cancer Detection.