Sequential Tracking of PD-L1 Expression and RAD50 Induction in Circulating Tumor and Stromal Cells of Lung Cancer Patients Undergoing Radiotherapy
Abstract
Purpose: Evidence suggests that PD-L1 can be induced with radiotherapy and may be an immune escape mechanism in cancer. Monitoring this response is limited, as repetitive biopsies during therapy are impractical, dangerous, and miss tumor stromal cells. Monitoring PD-L1 expression in both circulating tumor cells (CTCs) and circulating stromal cells (CStCs) in blood-based biopsies might be a practical alternative for sequential, noninvasive assessment of changes in tumor and stromal cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2017
- Source ID
- 10.1158/1078-0432.ccr-17-0802
Entities
People
- Cha-Mei Tang
- Daniel L Adams
- Diane K. Adams
- Hui Gao
- James M. Reuben
- Jianzhong He
- Martin J. Edelman
- Ming Zhang
- Neda Kalhor
- Ritsuko Komaki
- Steven H. Lin
- Ting Xu
- Yawei Qiao
- Zhongxing Liao
Organizations
- Army Research Office