Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer
Abstract
Purpose: Chemoresistance in triple-negative breast cancer (TNBC) is associated with the activation of a survival mechanism orchestrated by the endoplasmic reticulum (EnR) stress response and by inducible nitric oxide synthase (iNOS). Our aim was to determine the effects of pharmacologic NOS inhibition on TNBC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 28, 2018
- Source ID
- 10.1158/1078-0432.ccr-17-1437
Entities
People
- Anthony J. Kozielski
- Bhuvanesh Dave
- Daniel Dávila-gonzález
- Dong Soon Choi
- Helen Wong
- Jenny C. Chang
- John G. Kuhn
- Roberto R. Rosato
- Sergio M. Granados-principal
- Wei Qian
- Wen Chen
- Wen-feng Li
Organizations
- National Cancer Institute
- Pfizer
- Susan G. Komen for the Cure
- The Breast Cancer Research Foundation
- United States Department of Defense
- University of Texas at Austin