Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer
Abstract
Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dramatic and durable response to treatment. We sought to identify clinical, pathological, and molecular determinants of exceptional survival in women with high-grade serous cancer (HGSC), a disease associated with the majority of ovarian cancer deaths.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 31, 2018
- Source ID
- 10.1158/1078-0432.ccr-17-1621
Entities
People
- Alexander Dobrovic
- Alison Brand
- Ann-marie Patch
- Anna deFazio
- Anne Hamilton
- Bo Gao
- Brad H Nelson
- Catherine Emmanuel
- Catherine J Kennedy
- Colin J.r. Stewart
- Dale W Garsed
- Dariush Etemadmoghadam
- David D. L. Bowtell
- Elizabeth L Christie
- Giada V. Zapparoli
- Gisela Mir Arnau
- Jason Li
- Jillian Hung
- John V. Pearson
- Joshy George
- Joy Hendley
- Kathryn Alsop
- Katy Milne
- Kaushalya C Amarasinghe
- Linda Mileshkin
- Maartje C.a. Wouters
- Marisa Grossi
- Martin Köbel
- Michael Friedlander
- Nadia Traficante, For The Australian Ovarian Cancer Study Group
- Nicola Waddell
- Orla Mcnally
- Paul A. Cohen
- Paul Harnett
- Penny Blomfield
- Peter F. Rambau
- Philip Beale
- Prue E. Allan
- Raghwa Sharma
- Robert M. Rome
- Sean M. Grimmond
- Sian Fereday
- Sreeja R. Gadipally
- Sumitra Ananda
- Thomas Mikeska
- Timothy Semple
- Val Gebski
- Valérie Garès
- Yee C. Leung
- Yoke-eng Chiew
Organizations
- BC Cancer Agency
- Canadian Institutes of Health Research
- Cancer Australia
- Cancer Institute of New South Wales
- Epworth Freemasons
- Garvan Institute of Medical Research
- King Edward Memorial Hospital
- La Trobe University
- National Breast Cancer Foundation
- National Health and Medical Research Council
- Royal Hobart Hospital
- United States Army Medical Research and Development Command
- United States Department of Health and Human Services
- University of Calgary
- University of Melbourne
- University of New South Wales
- Westmead Hospital
- Westmead Institute for Medical Research