PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer
Abstract
Purpose: Intratumoral androgen synthesis (IAS) is a key mechanism promoting androgen receptor (AR) reactivation and antiandrogen resistance in castration-resistant prostate cancer (CRPC). However, signaling pathways driving aberrant IAS remain poorly understood.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 14, 2018
- Source ID
- 10.1158/1078-0432.ccr-17-2006
Entities
People
- Benyi Li
- Haojie Huang
- Jennifer J. Westendorf
- Jiaxiang Chen
- Jun Zhang
- Linlin Ma
- Manish Kohli
- Michael Hinten
- R. Jeffrey Karnes
- Runzhi Zhu
- Wanhai Xu
- Yang Bai
- Yinhui Yang
- Yu Zhao
- Yundong He
- Yunqian Pan
Organizations
- Harbin Medical University
- Jiangsu University
- Mayo Clinic
- Mayo Medical School
- National Institutes of Health
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province
- United States Department of Defense
- University of Kansas Medical Center