Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia
Abstract
Purpose: The intracellular redox environment of acute myeloid leukemia (AML) cells is often highly oxidized compared to healthy hematopoietic progenitors and this is purported to contribute to disease pathogenesis. However, the redox regulators that allow AML cell survival in this oxidized environment remain largely unknown.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 31, 2018
- Source ID
- 10.1158/1078-0432.ccr-17-2684
Entities
People
- Anushk Gupta
- Benjamin A Garcia
- Claudia Scholl
- Daniela Di Marcantonio
- Elena Masselli
- Esteban A Martinez
- Francesca Ferraro
- Giuliana Gobbi
- Grant A Challen
- Jake M. Meadows
- Jessica Vadaketh
- Marco Vitale
- Margaret Nieborowska-skorska
- Michael D. Milsom
- Prisco Mirandola
- Ramiro Garzon
- Siddharth Balachandran
- Simone Sidoli
- Stefan Fröhling
- Stephen M. Sykes
- Tomasz Skorski
Organizations
- Fox Chase Cancer Center
- German Cancer Research Center
- National Cancer Institute
- National Center for Tumor Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- Ohio State University
- Temple University School of Medicine
- United States Department of Defense
- University of Parma
- University of Pennsylvania
- Washington University School of Medicine