Surviving Ovarian Cancer: An Affair between Defective DNA Repair and RB1
Abstract
Detailed clinical and molecular evaluation of large cohorts of exceptional survivors provides an unprecedented opportunity to identify mechanisms underlying long-term survival that can drive future therapeutic approaches and biomarker development. Exceptional survivors of high-grade serous ovarian cancer demonstrate concurrent disruption of homologous recombination DNA repair and retinoblastoma protein. Clin Cancer Res; 24(3); 508–10. ©2017 AACR.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 31, 2018
- Source ID
- 10.1158/1078-0432.ccr-17-3022
Entities
People
- Gordon B. Mills
- Guang Peng
Organizations
- Cancer Prevention and Research Institute of Texas
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense
- University of Texas at Austin