SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy
Abstract
Purpose: Understanding the mechanism of radioresistance could help develop strategies to improve therapeutic response of patients with PDAC. The SMAD4 gene is frequently mutated in pancreatic cancer. In this study, we investigated the role of SMAD4 deficiency in pancreatic cancer cells' response to radiotherapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2018
- Source ID
- 10.1158/1078-0432.ccr-17-3435
Entities
People
- Chunying Yang
- Dickson Kirui
- Eugene J Koay
- Feng Wang
- Haifa Shen
- Han-cheon Kim
- Jason B. Fleming
- Jianliang Shen
- Junhua Mai
- Mauro Ferrari
- Sankar Mitra
- Xiaojun Xia
- Ya'an Kang
Organizations
- Houston Methodist Hospital
- Sun Yat-sen University
- Tongji University
- United States Department of Defense
- University of Texas at Austin
- Weill Cornell Medicine