[18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM
Abstract
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by inactivating mutations of the TSC1 or TSC2 gene, characterized by neurocognitive impairment and benign tumors of the brain, skin, heart, and kidneys. Lymphangioleiomyomatosis (LAM) is a diffuse proliferation of α-smooth muscle actin–positive cells associated with cystic destruction of the lung. LAM occurs almost exclusively in women, as a TSC manifestation or a sporadic disorder (TSC1/TSC2 somatic mutations). Biomarkers of whole-body tumor burden/activity and response to rapalogs or other therapies remain needed in TSC/LAM.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2018
- Source ID
- 10.1158/1078-0432.ccr-17-3693
Entities
People
- Carmen Priolo
- Chongzhao Ran
- Eline E Verwer
- Georges El Fakhri
- Jing Yang
- Kazue Takahashi
- Marc D. Normandin
- Marie F. Kijewski
- Nicolas J. Guehl
- Peter Sadow
- Ramesh Neelamegam
- Shuyan Wang
- Souheil El-chemaly
- Taylor R. Kavanagh
- Timothy M. Shoup
- Walter Massefski
- William J. Mischler
- William M Oldham
- Ye Cui
- You Feng
Organizations
- Harvard Medical School
- United States Department of Defense