SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer

Abstract

Adaptive antitumor immunity following ablative radiotherapy (ART) is attenuated by host myeloid-derived suppressor cell (MDSC), tumor-associated macrophage (TAM), and regulatory T-cell (Treg) infiltrates. We hypothesized treatment with ART and a secondary mitochondrial-derived activators of caspase (SMAC) mimetic could reverse the immunosuppressive lung cancer microenvironment to favor adaptive immunity.

Document Details

Document Type
Pub Defense Publication
Publication Date
Feb 01, 2019
Source ID
10.1158/1078-0432.ccr-17-3852

Entities

People

  • Bo Lu
  • GrĂ©goire Vuagniaux
  • Neal S. Mccall
  • Norbert Wiedemann
  • Zhen Tao
  • Zhiyong Yuan

Organizations

  • National Natural Science Foundation of China
  • Natural Science Foundation of Tianjin City
  • Thomas Jefferson University
  • Tianjin Medical University

Tags

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Oncology
  • Oncology (Cancer Research).