YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer
Abstract
Esophageal cancer is a lethal disease that is often resistant to therapy. Alterations of YAP1 and CDK6 are frequent in esophageal cancer. Deregulation of both molecules may be responsible for therapy resistance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1158/1078-0432.ccr-18-1029
Entities
People
- Ailing W. Scott
- Bovey Liu
- Fan Li
- Guangchun Han
- Heath D. Skinner
- Jaffer A. Ajani
- Jiankang Jin
- Kazuto Harada
- Lang Ma
- Linghua Wang
- Longfei Huo
- Melissa Pool Pizzi
- Min Xie
- Pankaj Kumar Singh
- Randy L Johnson
- Sheng Ding
- Shumei Song
- Sunil Krishnan
- Wei Zhao
- Xiaochuan Dong
- Yan Xu
- Ying Wang
- Yuan Li
Organizations
- Army Medical University
- National Institutes of Health
- United States Department of Defense
- University of California, San Francisco