Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor Lesions

Abstract

High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential to provide sensitive and specific detection of HGSOC at its earliest stages.

Document Details

Document Type
Pub Defense Publication
Publication Date
Dec 13, 2018
Source ID
10.1158/1078-0432.ccr-18-1199

Entities

People

  • Amanda Fader
  • Ie-Ming Shih
  • Kentaro Nakayama
  • Leslie M. Cope
  • Pornpat Athamanolap
  • Ryoichi Asaka
  • Shiou-Fu Lin
  • Thomas R. Pisanic Ii
  • Tian-li Wang
  • Ting-Tai Yen
  • Tza-Huei Wang

Organizations

  • Congressionally Directed Medical Research Programs
  • Johns Hopkins University
  • National Institutes of Health
  • Shimane University

Tags

Readers

  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.