Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC
Abstract
Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1158/1078-0432.ccr-18-3778
Entities
People
- Daniela Sia
- Josep M. Llovet
- Roser Pinyol
Organizations
- Cancer Research UK
- Catalan Institution for Research and Advanced Studies
- European Institute of Innovation and Technology
- Generalitat of Catalonia
- Horizon 2020
- Icahn School of Medicine at Mount Sinai
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense
- University of Barcelona