Mobilization of CD8+ T Cells via CXCR4 Blockade Facilitates PD-1 Checkpoint Therapy in Human Pancreatic Cancer
Abstract
Pancreatic ductal adenocarcinoma (PDA) is rarely cured, and single-agent immune checkpoint inhibition has not demonstrated clinical benefit despite the presence of large numbers of CD8+ T cells. We hypothesized that tumor-infiltrating CD8+ T cells harbor latent antitumor activity that can be reactivated using combination immunotherapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2019
- Source ID
- 10.1158/1078-0432.ccr-19-0081
Entities
People
- Arezou Abbasi
- Florencia G. Jalikis
- Harlan Robins
- Ian Nicholas Crispe
- James O. Park
- Kevin M. Sullivan
- Kimberly S. Smythe
- Marissa Vignali
- Raymond Yeung
- Robert H. Pierce
- Sara K. Daniel
- Seth M Pollack
- Teresa S Kim
- Venu G Pillarisetty
- Xiuyun Jiang
- Yongwoo David Seo
Organizations
- National Institutes of Health
- University of Washington