CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer
Abstract
The potential biological determinants of aggressive prostate cancer in African American (AA) men are unknown. Here we characterize prostate cancer genomic alterations in the largest cohort to date of AA men with clinical follow-up for metastasis, with the aim to elucidate the key molecular drivers associated with poor prognosis in this population.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2020
- Source ID
- 10.1158/1078-0432.ccr-19-1669
Entities
People
- Alexander S Baras
- Daniel E. Spratt
- Daniel H. Hovelson
- Daniela Correia Salles
- Edward M. Schaeffer
- Farzana A. Faisal
- Harsimar Kaur
- Jeffrey J Tosoian
- Kevin Hu
- Liana B. Guedes
- Sanjana Murali
- Scott A. Tomlins
- Sumin Han
- Tamara L Lotan
- Thiago Vidotto
- Vishal Kothari
Organizations
- Johns Hopkins University
- National Cancer Institute
- National Institutes of Health
- Northwestern University
- Prostate Cancer Foundation
- University of Michigan