Today's Special on the Anticancer Menu: Immunomodulation by Antifolates
Abstract
Pemetrexed is widely employed for the clinical management of mesothelioma and non–small cell lung carcinoma, largely based on its ability to curtail folate metabolism in highly proliferating cells. Recent preclinical findings suggest that the therapeutic efficacy of pemetrexed may involve an unsuspected immunologic component.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2019
- Source ID
- 10.1158/1078-0432.ccr-19-2775
Entities
People
- Aitziber Buqué
- Lorenzo Galluzzi
- Noelia Casares
Organizations
- United States Department of Defense
- Weill Cornell Medicine
- Yale School of Medicine