Proteomic Analysis of CSF from Patients with Leptomeningeal Melanoma Metastases Identifies Signatures Associated with Disease Progression and Therapeutic Resistance
Abstract
The development of leptomeningeal melanoma metastases (LMM) is a rare and devastating complication of the late-stage disease, for which no effective treatments exist. Here, we performed a multi-omics analysis of the cerebrospinal fluid (CSF) from patients with LMM to determine how the leptomeningeal microenvironment shapes the biology and therapeutic responses of melanoma cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2020
- Source ID
- 10.1158/1078-0432.ccr-19-2840
Entities
People
- Bin Fang
- Brittany Evernden
- Clayton Wyatt
- Eric A. Welsh
- Inna Smalley
- John Koomen
- Keiran S.m. Smalley
- Peter A. Forsyth
- Robert J. B. Macaulay
- Vincent Law
Organizations
- H. Lee Moffitt Cancer Center & Research Institute
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense