Comprehensive Genomic Analysis of Translocation Renal Cell Carcinoma Reveals Copy-Number Variations as Drivers of Disease Progression
Abstract
Translocation renal cell carcinoma (tRCC) is a rare, aggressive renal cell carcinoma (RCC) subtype. There is currently limited understanding on the role of molecular alterations in the pathogenesis and progression of these tumors. We investigated the association between somatic alterations and clinical outcomes in two independent cohorts profiled using DNA sequencing.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 15, 2020
- Source ID
- 10.1158/1078-0432.ccr-19-3283
Entities
People
- A Ari Hakimi
- Alejandro Sánchez
- Amar Sandhu
- Andrew W. Silagy
- Daniel E Nassau
- Ed Reznik
- Fengshen S. Kuo
- Jonathan Coleman
- Julian Marcon
- Kyle A Blum
- Maria I Carlo
- Martin H Voss
- Michael V. Ortiz
- Nicole E. Benfante
- Paul Russo
- Renzo G. DiNatale
- Ritesh R Kotecha
- Robert Motzer
- Roy Mano
- Sounak Gupta
- Timothy A Chan
- Victor Reuter
- Vladimir Makarov
Organizations
- German Research Foundation
- Memorial Sloan Kettering Cancer Center
- National Institutes of Health
- United States Department of Defense