Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)
Abstract
Gene expression–based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been hindered by nonstandardized methods, which are not applicable in a clinical setting. We sought to generate a clinical grade minimal gene set assay for classification of individual tumor specimens into HGSOC subtypes and confirm previously reported subtype-associated features.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 15, 2020
- Source ID
- 10.1158/1078-0432.ccr-20-0103
Entities
People
- Aleksandra Gentry-Maharaj
- Aleksandra Toloczko
- Alicia Beeghly-Fadiel
- Aline Talhouk
- Alison H. Brand
- Amy Lum
- Ana Osorio
- Andrew Berchuck
- Anna H. Wu
- Anna M. Piskorz
- Anna deFazio
- Aocs Group
- Beth Karlan
- Billy Chen
- Blake Gilks
- Boris Winterhoff
- Brenda Y. Hernandez
- Britton Trabert
- Casey S. Greene
- Catherine J Kennedy
- Celeste L. Pearce
- Cezary Cybulski
- Chen Wang
- Chiu-chen Tseng
- Chloe Karpinskyj
- Clara Bodelon
- Cristina Rodríguez-Antona
- Darren Ennis
- David D. Bowtell
- David G. Huntsman
- Dennis Slamon
- Derek S. Chiu
- Dilrini De Silva
- Dustin Johnson
- Ellen L Goode
- Esther Herpel
- Euan A. Stronach
- Gary L. Keeney
- Geoff Macintyre
- Georgia Chenevix-Trench
- Geyi Liu
- Gottfried E. Konecny
- Hanwei Sudderuddin
- Helen Steed
- Holly R Harris
- Honglin Song
- Huei San Leong
- Hugh Luk
- Iain A McNeish
- Isabelle Ray-coquard
- Jacek Gronwald
- James D Brenton
- Jan Lubinski
- Janine Senz
- Janusz Menkiszak
- Javier Benitez
- Jennifer A Doherty
- Jennifer Alsop
- Jennifer Koziak
- Jenny Chang-Claude
- Jenny Lester
- Jesus Garcia-donas
- Joellen M. Schildkraut
- Jolanta Lissowska
- Joshy George
- José Palacios
- Joy Hendley
- Kara L. Cushing-haugen
- Linda E Kelemen
- Liz-anne Lewsley
- Louise A. Brinton
- Lynne R. Wilkens
- Malcolm C Pike
- Marc T. Goodman
- Maria P. Intermaggio
- Mark E. Sherman
- Martin Köbel
- Martin Widschwendter
- Mary Anne Rossing
- María J. García
- Melissa C. Larson
- Mercedes Jimenez-linan
- Michael E. Carney
- Michael S Anglesio
- Michelle J Henderson
- Mila Volchek
- Nadia Traficante
- Naveena Singh
- Nicolas Wentzensen
- Nikilyn Nevins
- Oleg Oszurek
- Pamela J. Thompson
- Paul D P Pharoah
- Paul Haluska
- Peter A. Fasching
- Peter Sinn
- Raghwa Sharma
- Renée Turzanski Fortner
- Rex C. Bentley
- Robert Brown
- Robertson Mackenzie
- Rosalind Glasspool
- Ruby Yun-ju Huang
- Sabine Behrens
- Samantha Hinsley
- Samuel C.y. Leong
- Sandra Orsulic
- Scott H Kaufmann
- Sian Fereday
- Simon A Gayther
- Stacey J Winham
- Stefan Kommoss
- Stephanie Chen
- Susan J. Ramus
- Susana N. Banerjee
- Sven Mahner
- Tayyebeh M. Nazeran
- Teodora Goranova
- Timothy Budden
- Tuan Zea Tan
- Usha Menon
- Valerie Rhenius
- Veronica Chow
- Wafaa Elatre
- Yoke-eng Chiew
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- Adelson Foundation
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- Canada Excellence Research Chairs
- Canadian Institutes of Health Research
- Cancer Council New South Wales
- Cancer Council SA
- Cancer Council Tasmania
- Cancer Council Victoria
- Cancer Institute of New South Wales
- Cancer Research UK
- Duke University
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- Ludwig-Maximilians-Universität München
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- The Breast Cancer Research Foundation
- United States Army Medical Research and Development Command
- United States Department of Defense
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