Methylomic Landscapes of Ovarian Cancer Precursor Lesions
Abstract
The current paradigm in the development of high-grade serous ovarian carcinoma (HGSC) proposes that the majority of HGSCs arise from precursor serous tubal intraepithelial carcinoma (STIC) lesions of the fallopian tube. Here we survey genome-wide methylation in HGSC precursor lesions to identify genomic regions that exhibit high-specificity differential hypermethylation for potential use as biomarkers for detecting STIC and HGSC at stages when curative intervention likely remains feasible.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2020
- Source ID
- 10.1158/1078-0432.ccr-20-0270
Entities
People
- Hanru Sun
- Ie-Ming Shih
- Lihong Li
- Michael Considine
- Thomas R. Pisanic Ii
- Tian-li Wang
- Tza-Huei Wang
- Yeh Wang
Organizations
- Congressionally Directed Medical Research Programs
- Johns Hopkins School of Medicine
- Johns Hopkins University
- National Institutes of Health