Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma
Abstract
Chromosomal instability is a hallmark of cancer that results in broad and focal copy-number alterations (CNAs), two events associated with distinct molecular, immunologic, and clinical features. In hepatocellular carcinoma (HCC), the role of CNAs has not been thoroughly assessed. Thus, we dissected the impact of CNA burdens on HCC molecular and immune features.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2020
- Source ID
- 10.1158/1078-0432.ccr-20-1497
Entities
People
- Catherine E Willoughby
- Daniela Sia
- Itziar Salaverria
- Jordi Camps
- Josep M. Llovet
- Laia Bassaganyas
- Laura Torrens
- Maria Vila-casadesús
- Robert Montal
- Roger Esteban-fabró
- Roser Pinyol
- Sara Torrecilla
- Sebastià Franch-Expósito
- Vincenzo Mazzaferro
Organizations
- Catalan Institution for Research and Advanced Studies
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
- European Regional Development Fund
- Generalitat of Catalonia
- Icahn School of Medicine at Mount Sinai
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
- Ministry of Science of Spain
- National Cancer Institute
- Spanish Association Against Cancer
- United States Department of Defense
- University of Barcelona