Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation
Abstract
Identifying cancers with high PI3K pathway activity is critical for treatment selection and eligibility into clinical trials of PI3K inhibitors. Assessments of tumor signaling pathway activity need to consider intratumoral heterogeneity and multiple regulatory nodes.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 13, 2020
- Source ID
- 10.1158/1078-0432.ccr-20-2000
Entities
People
- Clyde Bango
- Giovanni Parmigiani
- Habiba Elfandy
- Kathryn L. Penney
- Konrad H Stopsack
- Lorelei A. Mucci
- Massimo Loda
- Michaela Bowden
- Philip W. Kantoff
- Svitlana Tyekucheva
- Thomas M. Roberts
- Travis A. Gerke
- Ying Huang
Organizations
- Dana–Farber Cancer Institute
- H. Lee Moffitt Cancer Center & Research Institute
- Harvard Medical School
- Harvard University
- Memorial Sloan Kettering Cancer Center
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense
- Weill Cornell Medicine