A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3–Specific CAR T Cells in Solid Tumors

Abstract

The limited efficacy of chimeric antigen receptor (CAR) T-cell therapies with solid malignancies prompted us to test whether epigenetic therapy could enhance the antitumor activity of B7-H3.CAR T cells with several solid cancer types.

Document Details

Document Type
Pub Defense Publication
Publication Date
Apr 02, 2021
Source ID
10.1158/1078-0432.ccr-20-2487

Entities

People

  • Bakhos A Tannous
  • Bowen Li
  • Fan Wu
  • Filippos Kontos
  • Guokai Pan
  • Hanqing Zhang
  • Heran Deng
  • Jianglong Zhong
  • Jiannan Wu
  • Jing Tian
  • Jinsong Li
  • Lile He
  • Liping Xiao
  • Lizao Zhang
  • Niu Liu
  • Qunxing Li
  • Soldano Ferrone
  • Song Fan
  • Teppei Yamada
  • Tian Tian
  • Tingting Cai
  • Weixiong Chen
  • Xiaobin Lv
  • Xinhui Wang
  • Xinyu Lin
  • Xinyuan Lei
  • Yanliang Zhu
  • Yu Peng
  • Zezhen Fang
  • Zhangsong Wang
  • Zhanpeng Ou
  • Zhaohui Yang
  • Zhiming Tu

Organizations

  • Fukuoka University
  • Guangzhou Science, Technology and Innovation Commission
  • Harvard Medical School
  • Nanchang University
  • Nanjing Medical University
  • National Institutes of Health
  • National Natural Science Foundation of China
  • Southeast University
  • Sun Yat-sen University
  • United States Department of Defense

Tags

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Biology and Genetics
  • Oncology