Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome–Like Acute Lymphoblastic Leukemia

Abstract

Systems biology approaches can identify critical targets in complex cancer signaling networks to inform new therapy combinations that may overcome conventional treatment resistance.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jul 01, 2021
Source ID
10.1158/1078-0432.ccr-21-0553

Entities

People

  • Chia-hui Chen
  • David Hottman Allen
  • Gregory M. Chen
  • Hannah Kim
  • Jason Xu
  • Joseph P. Loftus
  • Kai Tan
  • Kellyn Madden
  • Ruitao Zhang
  • Sarah K. Tasian
  • Yang Ding
  • Yuxuan Hu

Organizations

  • Canadian Institutes of Health Research
  • Children's Hospital of Philadelphia
  • National Cancer Institute
  • National Institutes of Health
  • Temple University
  • United States Department of Defense
  • University of Pennsylvania
  • Xidian University

Tags

Readers

  • Oncology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech