Therapeutic Escape in Gαq-mutant Uveal Melanoma: It's a FAK
Abstract
Through a synthetic lethal screen, ERK activation was found to mediate resistance to FAK inhibition in GNAQ-mutant uveal melanoma. With PLCB-PKC-ERK and Trio-FAK-Yap representing compensatory effectors of mutant Gαq signaling, combined inhibition of both pathways may be a promising therapeutic strategy in metastatic uveal melanoma.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 25, 2021
- Source ID
- 10.1158/1078-0432.ccr-21-0567
Entities
People
- J William Harbour
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Miami