Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases
Abstract
Melanoma brain metastases (MBM) and leptomeningeal melanoma metastases (LMM) are two different manifestations of melanoma CNS metastasis. Here, we used single-cell RNA sequencing (scRNA-seq) to define the immune landscape of MBM, LMM, and melanoma skin metastases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 25, 2021
- Source ID
- 10.1158/1078-0432.ccr-21-1694
Entities
People
- Amod Sarnaik
- Arnold B. Etame
- Brittany Evernden
- Chaomei Zhang
- Clayton Wyatt
- Inna Smalley
- Jane L Messina
- Jiannong Li
- Keiran S.m. Smalley
- Manali Phadke
- Nam Tran
- Paulo C Rodriguez
- Peter Forsyth
- Robert J. B. Macaulay
- Vernon K. Sondak
- Vincent Law
- Xiaoqing Yu
- Y. Ann Chen
- Zeynep Eroglu
- Zhihua Chen
Organizations
- H. Lee Moffitt Cancer Center & Research Institute
- Melanoma Research Foundation
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense