Circulating and Intratumoral Adrenal Androgens Correlate with Response to Abiraterone in Men with Castration-Resistant Prostate Cancer
Abstract
In metastatic castration-resistant prostate cancer (mCRPC) low serum androgens prior to starting abiraterone acetate (AA) is associated with more rapid progression. We evaluated the effect of AA on androgens in castration-resistant prostate cancer (CRPC) metastases and associations of intratumoral androgens with response.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 18, 2021
- Source ID
- 10.1158/1078-0432.ccr-21-1819
Entities
People
- Alvin Matsumoto
- Brett T. Marck
- Elahe A. Mostaghel
- Evan Y. Yu
- Felix S Chew
- Heather H Cheng
- Mary-ellen Taplin
- Michael T Schweizer
- Nima Sharifi
- Orpheus Kolokythas
- Peter S Nelson
- Phillip W. Kantoff
- R. Bruce Montgomery
- Steven P Balk
Organizations
- Cleveland Clinic
- Harvard Medical School
- Pacific Northwest Foundation
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Washington
- VA Puget Sound Health Care System