Metabolic Alterations and WNT Signaling Impact Immune Response in HGSOC
Abstract
Our study used transcriptomic and metabolomic strategies to determine the molecular profiles of HGSOC patient samples derived from primary tumor and ascites cells. These data identified clinically relevant heterogeneity among and within patients and highlighted global and patient-specific cellular responses to neoadjuvant chemotherapy (NACT).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 13, 2022
- Source ID
- 10.1158/1078-0432.ccr-21-2984
Entities
People
- Allison M. Davis
- Bobbi E. Johnston
- Carly Bess Williams
- David K. Crossman
- Emily R. Gordon
- Mckenzie E. Foxall
- Rebecca C Arend
- Sara Cooper
Organizations
- United States Department of Defense
- University of Alabama at Birmingham