Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition
Abstract
The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels change is not known because of the inability to longitudinally assess vascular and interstitial oxygen in tumors with sufficient resolution. Understanding the spatial and temporal heterogeneity should help improve the outcome of various normalization strategies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 23, 2022
- Source ID
- 10.1158/1078-0432.ccr-22-0486
Entities
People
- Ahmed S. Mousa
- Dai Fukumura
- Dan G Duda
- Edward B Brown
- Hang Lee
- Hee-Sun Han
- John D Martin
- Margaret R. Martin
- Moungi Bawendi
- Rakesh Jain
- Ryan M. Lanning
- Timothy P Padera
- Triantafyllos Stylianopoulos
- Vikash P. Chauhan
- Walid S. Kamoun
Organizations
- Harvard Medical School
- Harvard University
- Massachusetts Institute of Technology
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense