MENA Promotes Tumor-Intrinsic Metastasis through ECM Remodeling and Haptotaxis
Abstract
Summary: Oudin and colleagues report a novel and specific function of MENA in mediating directional migration of breast cancer cells toward a fibronectin gradient of increasing concentration. This MENA-mediated haptotactic response depends on the binding of MENA to the α5β1 integrin receptor, adhesion protein signaling, and fibronectin fibrillogenesis. Cancer Discov; 6(5); 474–6. ©2016 AACR.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2016
- Source ID
- 10.1158/2159-8290.cd-16-0231
Entities
People
- Jing Yang
- Miguel Santiago-medina
Organizations
- National Cancer Institute
- United States Department of Defense
- University of California, San Diego