TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
Abstract
TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2020
- Source ID
- 10.1158/2159-8290.cd-20-0451
Entities
People
- Emmanuel S. Antonarakis
- Konrad H Stopsack
- Lorelei A. Mucci
- Peter S Nelson
- Philip W. Kantoff
Organizations
- Harvard University
- Johns Hopkins University
- Memorial Sloan Kettering Cancer Center
- Prostate Cancer Foundation
- United States Department of Defense
- University of Washington