Biomolecular Condensation: A New Phase in Cancer Research
Abstract
Multicellularity was a watershed development in evolution. However, it also meant that individual cells could escape regulatory mechanisms that restrict proliferation at a severe cost to the organism: cancer. From the standpoint of cellular organization, evolutionary complexity scales to organize different molecules within the intracellular milieu. The recent realization that many biomolecules can “phase-separate” into membraneless organelles, reorganizing cellular biochemistry in space and time, has led to an explosion of research activity in this area. In this review, we explore mechanistic connections between phase separation and cancer-associated processes and emerging examples of how these become deranged in malignancy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 19, 2022
- Source ID
- 10.1158/2159-8290.cd-21-1605
Entities
People
- Anupam K. Chakravarty
- Brandon S Dunn
- Daniel F Jarosz
- Daniel McGrail
- David J. H. Shih
- Gordon B. Mills
- Kara M. Cirillo
- Nidhi Sahni
- Song Yi
- Sueda Cetinkaya
- Sueda H. Cetinkaya
- Thomas M. Lozanoski
Organizations
- Baylor College of Medicine
- Cancer Prevention and Research Institute of Texas
- Cleveland Clinic
- Damon Runyon Cancer Research Foundation
- Gordon and Betty Moore Foundation
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institutes of Health
- National Science Foundation
- Oregon Health & Science University
- Stanford University
- United States Department of Defense
- University of Michigan
- University of Texas Health Science Center at Houston
- University of Texas at Austin