Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models of Hereditary Hemorrhagic Telangiectasia
Abstract
Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease caused by mutations in ENG , ALK1 , or SMAD4 . Since proteins from all 3 HHT genes are components of signal transduction of TGF-β (transforming growth factor β) family members, it has been hypothesized that HHT is a disease caused by defects in the ENG-ALK1-SMAD4 linear signaling. However, in vivo evidence supporting this hypothesis is scarce.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 09, 2020
- Source ID
- 10.1161/circresaha.119.316267
Entities
People
- Calvin P.h. Vary
- Chang-jin Jeon
- Helen M. Arthur
- Phuong-nhung Vu
- Se-Woon Choe
- Suk Paul Oh
- Yong Hwan Kim
- Young Jae Lee
Organizations
- Barrow Neurological Institute
- British Heart Foundation
- Gachon University
- Kumoh National Institute of Technology
- Kyungpook National University
- National Institutes of Health
- National Research Foundation of Korea
- Newcastle University
- United States Department of Defense
- University of Florida