Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression
Abstract
Regression of atherosclerosis is an important clinical goal; however, the pathways that mediate the resolution of atherosclerotic inflammation and reversal of plaques are poorly understood. Regulatory T cells (Tregs) have been shown to be atheroprotective, yet the numbers of these immunosuppressive cells decrease with disease progression, and whether they contribute to atherosclerosis regression is not known.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 17, 2020
- Source ID
- 10.1161/circresaha.119.316461
Entities
People
- Ada Weinstock
- Brian E. Sansbury
- Coen Van Solingen
- Daniel Peled
- Edward A Fisher
- Emily J. Brown
- Emma M. Corr
- Graeme J. Koelwyn
- Juan J. Lafaille
- Karishma Rahman
- Kathryn J. Moore
- Lauren Beckett
- Lianne C. Shanley
- Martin P. Schlegel
- Matthew Spite
- Milessa S. Afonso
- Monika Sharma
- P'ng Loke
Organizations
- Grossman School of Medicine
- Harvard Medical School
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- New York University
- United States Department of Defense