Dach1 Extends Artery Networks and Protects Against Cardiac Injury
Abstract
Coronary artery disease is the leading cause of death worldwide, but there are currently no methods to stimulate artery growth or regeneration in diseased hearts. Studying how arteries are built during development could illuminate strategies for re-building these vessels during ischemic heart disease. We previously found that Dach1 deletion in mouse embryos resulted in small coronary arteries. However, it was not known whether Dach1 gain-of-function would be sufficient to increase arterial vessels and whether this could benefit injury responses.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 17, 2021
- Source ID
- 10.1161/circresaha.120.318271
Entities
People
- Alana Nguyen
- Andrew H Chang
- Brian Raftrey
- Daniel Bernstein
- Emily Trimm
- Gaetano D’amato
- Ian M Williams
- Karen M. Gonzalez
- Kristy Red-Horse
- Kyle M. Loh
- Lay Teng Ang
- Mingming Zhao
- Pamela E. Rios Coronado
- R A Roth
- Ragini Phansalkar
- Raquel Racelis
- Timothy Chai
- Xiaochen Fan
- Yue Zhang
Organizations
- National Heart, Lung, and Blood Institute
- Stanford University
- Stanford University School of Medicine
- United States Department of Defense