An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts

Abstract

While respiratory failure is a frequent and clinically significant outcome of coronavirus disease 2019 (COVID-19), cardiac complications are a common feature in hospitalized COVID-19 patients and are associated with worse patient outcomes. The cause of cardiac injury in COVID-19 patients is not yet known. Case reports of COVID-19 autopsy heart samples have demonstrated abnormal inflammatory infiltration of macrophages in heart tissues.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 25, 2021
Source ID
10.1161/circresaha.121.319060

Entities

People

  • Alain Borczuk
  • Benjamin E. Nilsson-payant
  • Benjamin R tenOever
  • Chanel Richardson
  • David D Ho
  • David Redmond
  • Fabrice Jaffré
  • Jean K Lim
  • Jenny Xiang
  • Jiajun Zhu
  • Joshua A. Acklin
  • Liuliu Yang
  • Pengfei Wang
  • Robert E. Schwartz
  • Sean Houghton
  • Shuibing Chen
  • Skyler Uhl
  • Todd Evans
  • Tuo Zhang
  • Vasuretha Chandar
  • Yaoxing Huang
  • Yaron Bram
  • Yuling Han
  • Zhengming Chen

Organizations

  • American Heart Association
  • Columbia University
  • Division of Intramural Research, National Institute of Allergy and Infectious Diseases
  • Gates Foundation
  • Icahn School of Medicine at Mount Sinai
  • National Cancer Institute
  • National Heart, Lung, and Blood Institute
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • Weill Cornell Medicine

Tags

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Infectious Disease/Epidemiology