Local connectome phenotypes predict social, health, and cognitive factors
Abstract
The unique architecture of the human connectome is defined initially by genetics and subsequently sculpted over time with experience. Thus, similarities in predisposition and experience that lead to similarities in social, biological, and cognitive attributes should also be reflected in the local architecture of white matter fascicles. Here we employ a method known as local connectome fingerprinting that uses diffusion MRI to measure the fiber-wise characteristics of macroscopic white matter pathways throughout the brain. This fingerprinting approach was applied to a large sample ( N = 841) of subjects from the Human Connectome Project, revealing a reliable degree of between-subject correlation in the local connectome fingerprints, with a relatively complex, low-dimensional substructure. Using a cross-validated, high-dimensional regression analysis approach, we derived local connectome phenotype (LCP) maps that could reliably predict a subset of subject attributes measured, including demographic, health, and cognitive measures. These LCP maps were highly specific to the attribute being predicted but also sensitive to correlations between attributes. Collectively, these results indicate that the local architecture of white matter fascicles reflects a meaningful portion of the variability shared between subjects along several dimensions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2018
- Source ID
- 10.1162/netn_a_00031
Entities
People
- Fang-Cheng Yeh
- Javier O Garcia
- Jean M Vettel
- Michael A. Powell
- Timothy Verstynen
Organizations
- Carnegie Mellon University
- United States Army Research Laboratory
- University of California, Santa Barbara
- University of Pennsylvania
- University of Pittsburgh
- University of Pittsburgh Medical Center