Functional control of electrophysiological network architecture using direct neurostimulation in humans
Abstract
Chronically implantable neurostimulation devices are becoming a clinically viable option for treating patients with neurological disease and psychiatric disorders. Neurostimulation offers the ability to probe and manipulate distributed networks of interacting brain areas in dysfunctional circuits. Here, we use tools from network control theory to examine the dynamic reconfiguration of functionally interacting neuronal ensembles during targeted neurostimulation of cortical and subcortical brain structures. By integrating multimodal intracranial recordings and diffusion-weighted imaging from patients with drug-resistant epilepsy, we test hypothesized structural and functional rules that predict altered patterns of synchronized local field potentials. We demonstrate the ability to predictably reconfigure functional interactions depending on stimulation strength and location. Stimulation of areas with structurally weak connections largely modulates the functional hubness of downstream areas and concurrently propels the brain towards more difficult-to-reach dynamical states. By using focal perturbations to bridge large-scale structure, function, and markers of behavior, our findings suggest that stimulation may be tuned to influence different scales of network interactions driving cognition.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2019
- Source ID
- 10.1162/netn_a_00089
Entities
People
- Ankit Khambhati
- Ari E Kahn
- Barbara C. Jobst
- Bradley C Lega
- Daniel S Rizzuto
- Danielle Bassett
- Ethan A Solomon
- Gregory Worrell
- Joel M Stein
- Joseph I. Tracy
- Julia Costantini
- Kareem A Zaghloul
- Kathryn A Davis
- Michael J. Kahana
- Michael R Sperling
- Richard Gorniak
- Robert E Gross
- Sameer A. Sheth
- Sandhitsu R. Das
- Sarah Seger
- Shennan Weiss
- Timothy H. Lucas
- Youssef Ezzyat
Organizations
- Alfred P. Sloan Foundation
- Baylor College of Medicine
- Dartmouth–Hitchcock Medical Center
- Defense Advanced Research Projects Agency
- Emory University
- Foundation for the National Institutes of Health
- Hospital of the University of Pennsylvania
- John D. and Catherine T. MacArthur Foundation
- Mayo Clinic
- National Institutes of Health
- National Science Foundation
- Thomas Jefferson University
- United States Army Research Laboratory
- United States Naval Research Laboratory
- University of Pennsylvania
- University of Texas at Austin