Application of biomaterials and nanotechnology in corneal tissue engineering
Abstract
Corneal diseases are among the most common causes of blindness worldwide. Regardless of the etiology, corneal opacity- or globe integrity-threatening conditions may necessitate corneal replacement procedures. Several procedure types are currently available to address these issues, based on the complexity and extent of injury. Corneal allograft or keratoplasty is considered to be first-line treatment in many cases. However, a significant proportion of the world’s population are reported to have no access to this option due to limitations in donor preparation. Thus, providing an appropriate, safe, and efficient synthetic implant (e.g., artificial cornea) may revolutionize this field. Nanotechnology, with its potential applications, has garnered a lot of recent attention in this area, however, there is seemingly a long way to go. This narrative review provides a brief overview of the therapeutic interventions for corneal pathologies, followed by a summary of current biomaterials used in corneal regeneration and a discussion of the nanotechnologies that can aid in the production of superior implants.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2023
- Source ID
- 10.1177/03000605231190473
Entities
People
- Ali R Djalilian
- Arthur Y. Chang
- Hamed Ghasemi
- Kasra Cheraqpour
- Kosar Sadat Ebrahimi
- Mohammad Soleimani
- Mohsen Shahlaei
- Negin Farhadian
- Sajad Moradi
- Seyed Mahbod Baharnoori
- Sina Sharifi
- Zohreh Ebrahimi
Organizations
- Kermanshah University of Medical Sciences
- Massachusetts Eye and Ear Infirmary
- Research to Prevent Blindness
- Tehran University of Medical Sciences
- United States Department of Defense
- University of Illinois at Chicago