Dynamic Compressive Loading Improves Cartilage Repair in an In Vitro Model of Microfracture: Comparison of 2 Mechanical Loading Regimens on Simulated Microfracture Based on Fibrin Gel Scaffolds Encapsulating Connective Tissue Progenitor Cells
Abstract
Microfracture of focal chondral defects often produces fibrocartilage, which inconsistently integrates with the surrounding native tissue and possesses inferior mechanical properties compared with hyaline cartilage. Mechanical loading modulates cartilage during development, but it remains unclear how loads produced in the course of postoperative rehabilitation affect the formation of the new fibrocartilaginous tissue.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2019
- Source ID
- 10.1177/0363546519855645
Entities
People
- Benjamin B Rothrauff
- Freddie H. Fu
- Hiroshi Sasaki
- Riccardo Gottardi
- Rocky Tuan
- Shinichi Yoshiya
- Shinsuke Kihara
- Tomoya Iseki
Organizations
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Hyogo College of Medicine
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of Neurological Disorders and Stroke
- The Chinese University of Hong Kong
- United States Department of Defense
- University of Pittsburgh