Circadian Control of Glial Cell Homeodynamics
Abstract
The molecular mechanisms that maintain circadian rhythms in mammalian as well as non-mammalian systems are well documented in neuronal populations but comparatively understudied in glia. Glia are highly dynamic in form and function, and the circadian clock provides broad dynamic ranges for the maintenance of this homeostasis, thus glia are key to understanding the role of circadian biology in brain function. Here, we highlight the implications of the molecular circadian clock on the homeodynamic nature of glia, underscoring the current gap in understanding the role of the circadian system in oligodendroglia lineage cells and subsequent myelination. Through this perspective, we will focus on the intersection of circadian and glial biology and how it interfaces with global circadian rhythm maintenance associated with normative and aberrant brain function.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 06, 2022
- Source ID
- 10.1177/07487304221120966
Entities
People
- Anna Badner
- Daniela Rojo
- Erin M. Gibson
Organizations
- National Multiple Sclerosis Society
- Stanford University
- United States Department of Defense