Hippocampal vulnerability to hyperhomocysteinemia worsens pathological outcomes of mild traumatic brain injury in rats
Abstract
Mild traumatic brain injury (mTBI) generally resolves within weeks. However, 15-30% of patients present persistent pathological and neurobehavioral sequelae that negatively affect their quality of life. Hyperhomocysteinemia (HHCY) is a neurotoxic condition derived from homocysteine accumulation above 15 μM. HHCY can occur in diverse stressful situations, including those sustained by U.S. active-duty service members on the battlefield or during routine combat practice. Mild-TBI accounts for more than 80% of all TBI cases, and HHCY exists in 5-7% of the general population. We recently reported that moderate HHCY exacerbates mTBI-induced cortical injury pathophysiology, including increased oxidative stress. Several studies have demonstrated hippocampus vulnerability to oxidative stress and its downstream effects on inflammation and cell death.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 06, 2023
- Source ID
- 10.1177/11795735231160025
Entities
People
- Adam Puche
- Flaubert Tchantchou
- Gary Fiskum
- Ru-ching Hsia
Organizations
- Air Force Office of Scientific Research
- University of Maryland School of Medicine