In vivo detection of connectivity between cortical and white matter lesions in early MS
Abstract
The relationship between cortical lesions (CLs) and white matter lesions (WMLs) in multiple sclerosis (MS) is poorly understood. Pathological studies support a topographical association between CLs and underlying subcortical WMLs and suggest CLs may play a role in both disease initiation and progression. We hypothesized that cortical MS lesions are physically connected to white matter MS lesions via axonal connections.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 03, 2016
- Source ID
- 10.1177/1352458516671027
Entities
People
- Claudia F. Lucchinetti
- Istvan Pirko
- Jan-mendelt Tillema
- Jay Mandrekar
- John D. Port
- Stephen D. Weigand
- Yunhong Shu
Organizations
- Mayo Clinic
- National Center for Advancing Translational Sciences
- United States Department of Defense