Design and logistical considerations for the randomized adaptive non-inferiority storage-duration-ranging CHIlled Platelet Study
Abstract
Platelet transfusion is a potentially life-saving therapy for actively bleeding patients, ranging from those undergoing planned surgical procedures to those suffering unexpected traumatic injuries. Platelets are currently stored at room temperature (20°C–24°C) with a maximum storage duration of 7 days after donation. The CHIlled Platelet Study trial will compare the efficacy and safety of standard room temperature–stored platelets with platelets that are cold-stored (1°C–6°C), that is, chilled, with a maximum of storage up to 21 days in adult and pediatric patients undergoing complex cardiac surgical procedures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 21, 2022
- Source ID
- 10.1177/17407745221126423
Entities
People
- Elizabeth Krachey
- J. Michael Dean
- John VanBuren
- Kert Viele
- Marie E. Steiner
- Nicholas Berry
- Nicole D Zantek
- Philip C Spinella
- Roger J Lewis
- Stacy Nelson
Organizations
- Harbor–UCLA Medical Center
- United States Army Medical Research and Development Command
- University of California, Los Angeles
- University of Minnesota
- University of Pittsburgh
- University of Utah