The DNA damage repair landscape in Black women with breast cancer
Abstract
Estrogen receptor positive (ER+) breast cancer is one of the most commonly diagnosed malignancies in women irrespective of their race or ethnicity. While Black women with ER+ breast cancer are 42% more likely to die of their disease than White women, molecular mechanisms underlying this disparate outcome are understudied. Recent studies identify DNA damage repair (DDR) genes as a new class of endocrine therapy resistance driver that contributes to poor survival among ER+ breast cancer patients. Here, we systematically analyze DDR regulation in the tumors and normal breast of Black women and its impact on survival outcome.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1177/17588359221075458
Entities
People
- Aloran Mazumder
- Athena Jimenez
- Matthew N Bainbridge
- Rachel E Ellsworth
- Sophia George
- Stephen J. Freedland
- Svasti Haricharan
Organizations
- Durham VA Medical Center
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- National Cancer Institute
- Susan G. Komen for the Cure
- United States Department of Defense
- University of Miami