Association of proton pump inhibitor use with survival outcomes in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
Abstract
Proton pump inhibitors (PPIs) have been shown to regulate the gut microbiome and affect the response to immune checkpoint inhibitors (ICIs). Contradictory results on survival have been observed in patients concomitantly treated with ICIs and PPIs. We performed a systematic review and meta-analysis to determine the association between PPI use and survival outcomes in ICI-treated cancer patients.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1177/17588359221111703
Entities
People
- Baoqing Chen
- David Horst
- Dongmei Chi
- George A. Calin
- Mihnea P. Dragomir
- Qiaoqiao Li
- Wenyan Chen
- Yang Chen
Organizations
- Berlin Institute for Health Research
- Deutschen Konsortium für Translationale Krebsforschung
- Freie Universität Berlin
- German Cancer Research Center
- National Cancer Institute
- National Institute of General Medical Sciences
- National Natural Science Foundation of China
- Sun Yat-sen University
- United States Department of Defense
- University of Texas at Austin