Resveratrol and Curcumin AttenuateEx VivoSugar-Induced Cartilage Glycation, Stiffening, Senescence, and Degeneration

Abstract

Advanced glycation end-product (AGE) accumulation is implicated in osteoarthritis (OA) pathogenesis in aging and diabetic populations. Here, we develop a representative nonenzymatic glycation-induced OA cartilage explant culture model and investigate the effectiveness of resveratrol, curcumin, and eugenol in inhibiting AGEs and the structural and biological hallmarks of cartilage degeneration.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Jan 20, 2021
• Source ID: 10.1177/1947603520988768

Entities

People

• Ambika G. Bajpayee
• Cameron C. Young
• Justin D. Crane
• Matthew R. Warren
• Sandra J. Shefelbine
• Shikhar Mehta
• Sumayyah Akhtar

Organizations

• National Institutes of Health
• Northeastern University
• United States Department of Defense

Tags

Readers

• Molecular Biology and Genetics
• Neurotrauma and Rehabilitation Medicine.
• Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.